Can CBD stop Canine Epileptic Seizures?

Watching a dog have a seizure is terrifying. Especially if it's a dog you love.

 

Here at Cannimal we receive weekly calls from animal guardians hoping to treat their dog's seizures and epilepsy. This can be due to genetics but lately more and more calls are coming from in from animals who were taking oral heart worm or flea meds!

There can be serious side effects resulting from the use of conventional anticonvulsants- like phenobarbital- that many dogs are prescribed to control seizures.

These can include nausea, headaches, loss of hair, swelling of gum tissue, depression, poor coordination (ataxia), liver failure, depressed blood counts, sedation, unsteadiness, double vision, weight gain, hyperactivity, sleep disturbances, irritability, gum dysplasia, hirsutism (excessive growth of hair) and changes in mood.

Enter CBD

A 2013 study published by the British Journal of Pharmacology found that Cannabinoid based medicine can stop seizures due to its “significant anticonvulsant effects.” Using the substance on a number of animal models such as rats and mice, they found that the extract was able to effectively stop seizures. Researchers noted, “Here, for the first time, we demonstrate that cannabis extracts rich in CBDV and CBD can exert significant anticonvulsant effects…

The American Epilepsy Society published a study confirming that CBD oil is effective in treating seizures stating that CBD reduces the frequency of these seizures by 45%. 

Considering how devastating seizures can be for both the animal and their human family, this kind of success rate makes CBD a true GIFT to our planet.

 How can Cannimal help support your animal?

Animal guardians are using both our RELAX and WELLNESS Formulas for seizure dogs with amazing success.

Whether you are treating seizures, acute anxiety or chronic separation anxiety, Cannimal’s RELAX Formula is a unique formula unlike anything else… First, it combines the power of Full Spectrum CBD with the calming qualities of Passionflower and its ability to elicit GABA currents in the brain.
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GABA has an inhibitory effect on the brain, accounting for Passionflower’s anxiolytic (anti-anxiety) AND anticonvulsant (anti-seizure) properties. Studies show Passionflower has a similar effect as diazepam (Valium) without the pharmaceutical side effects.

 

 

Meet beautiful and brave seizure dog Rhea 💕

12/18/18 Hi I hope all is well. Just wanted to give you an update. Rhea has a couple more seizures but they were not even half as bad as before. I found by giving her the cbd while seizing she pretty much came right out of it. We have also gave it to her when we noticed her just about to go into in and gave her 5 pumps and omg no seizures. We are beyond the moon and keeping the faith that we will be able to fully remove her meds when your cbd is full effect😊😊😊

12/28/18 Hi Erika! She still is seizing but no more clusters, the length of them are definitely shorter and I am positive it is @cannimal_ Relax Formula that broke the clusters...

We are so thrilled definitely a step in the right direction! We are staying positive that in the next couple months she will go on a seizure free period for longer lengths of time. Right now her seizures are once a week - before starting your oil she was every 2-3 days!

1/2/19 I just have to tell you that she was going into a seizure with a head shake. My husband was able to pump in her mouth which he believes 10 pumps. It stopped almost immediately she didn't go into a Grand Mal!

 

Unfortunately, seizures are very common in dogs. Idiopathic epilepsy, the single most common canine seizure disorder, is reported to occur in anywhere from 0.5 to 5.7 percent of all dogs. 

Epilepsy is a persistent (chronic) condition of the brain.  It involves unpredictable abnormal electrical discharges or misfiring of brain cells (neurons).  This misfiring in the brain can cause episodes of bodily convulsions, loss of coordination, loss of consciousness or altered sensory states. 

Did you know the FDA issued a warning about four chewable flea and tick medications? The warning cautions that the products could lead to neurological issues such as seizures. The brands are isoxazoline-based Bravecto, Credelio, Nexgard or Simparica.

 

 

Romeo is an 10 year old dog that started having grand mal seizures 4 years ago.  Untreated, Romeo would have 3 to 4 seizures a week.  After being on a seizure medication for one year the medication became ineffective and Romeo started having seizures, requiring a change in medication. 
In April 2018, the veterinary neurologist prescribed phenobarbital for Romeo.  Three weeks later Romeo had his first pancreatitis bout.  He had never had pancreatitis before.  We researched phenobarbital and found that pancreatitis is a side effect of phenobarbital.  We discussed our findings with the veterinary neurologist who said it was highly unlikely and would not change his prescribed medication. 
Our primary vet made suggestions regarding dietary changes that were implemented.  We discussed the possibility of treating Romeo with Cannimal Relas CBD oil to our primary vet and neurologist vet and both said it would not be effective. 
In September 2018 Romeo had another bout of pancreatitis but again the neurologist claimed it was not associated with the medication. In December 2018 Romeo had his third bout of pancreatitis. Neither our primary vet or neurological vet knew what we could do to help eliminate these pancreatitis bouts. We were instructed to just get him into the emergency clinic as soon as the symptoms commenced. 
This proposal was unacceptable approach because it is not the way we want to manage our dogs health issues and every pancreatitic bout damages the pancreas and other internal organs. 
So in December 2018 I started giving Romeo Cannimal Relax Formula. After a couple of weeks on the Relax Formula, I slowly started lowering Romeo's phenobarbital dose. 
Now Romeo is off the phenobarbital and seizure free, hopefully forever… THANK YOU Cannimal for saving Romeo's life!

Fortunately, Cannabis has well documented relief for humans as well as animals who find themselves battling this disorder. Cannabis has been used to treat epilepsy since at least medieval Arabia and sixteenth-century Southeast Asia. In 1839 Dr. William O’Shaughnessy introduced Cannabis to Western medicine and it was used to treat convulsions caused by tetanus (lockjaw) and hydrophobia (rabies) along with puerperal convulsions, chorea, and strychnine poisoning.

A 2013 study published by the British Journal of Pharmacology found that marijuana can stop seizures due to its “significant anticonvulsant effects.” Researchers used an extract made from the whole cannabis plant. Using the substance on a number of animal models such as rats and mice, they found that the extract was able to effectively stop seizures.

Researchers noted, “Here, for the first time, we demonstrate that cannabis extracts rich in CBDV and CBD can exert significant anticonvulsant effects… These findings strongly support the further clinical development of CBDV BDSs for treatment of epilepsy.”

 

Dr. Paul Consroe of the University of Arizona suggests that CBD may have distinctive therapeutic value as an anticonvulsant in and of itself. He found that while high doses of THC can trigger convulsions in seizure susceptible animals, the administration of cannabidiol (CBD) in similar or higher does not cause convulsions.  His studies concluded that CBD might have powerful anticonvulsant properties, which counteract the muscle-exciting effects of THC when both compounds are delivered to the body in marijuana. 

CBD has demonstrated the ability to reduce or even eliminate seizures (Blair, Deshpande & DeLorenzo, 2015) (Rosenberg, Tsien, Whalley & Devinsky, 2015) (Szaflarski & Bebin, 2014) (Devinsky, et al., 2014).

 

ANOTHER HAPPY CANNIMAL! Handsome Gaston @gaston_aka_chunk

“Just got Gaston’s pheno levels results and they have gone down significantly ! He’s still on the phenobarbital for his seizures but I’ve been able to cut down on the dosage and I 100% give credit to Your CBD oil. My plan is to continue to cut the dosage slowly until I can get him off and have him on 100% cbd oil only ! We’re so happy!”

Research also finds that cannabinoids are effective in the treatment of severe pediatric epilepsy disorders like Dravet syndrome, Doose syndrome and Lennox-Gastaut syndrome (Porter & Jacobson, 2013).

CBD has also been shown to improve sleep (53%), alertness (71%), and mood (63%) in epileptic children (Hussain, et al., 2015).

References: Blair, R.E., Deshpande, L.S., and  DeLorenzo, R.J. (2015, September). Cannabinoids: is there a potential treatment role in epilepsy? Expert Opinion on Pharmacology, 16(13), 1911-4. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845642/.

Hussain, SA., Zhou, R., Jacobson, C., Weng, J., Cheng, E., Lay, J., Hung, P., Lerner, JT., and Sankar, R. (2015, June). Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome. Epilepsy & Behavior, 47, 138-41. Retrieved from http://www.epilepsybehavior.com/article/S1525-5050(15)00157-2/fulltext.

Szaflarski, JP. and Bebin, EM. (2014, December). Cannabis, cannabidiol, and epilepsy–from receptors to clinical response. Epilepsy & Behavior, 41, 277-82. Retrieved from http://www.epilepsybehavior.com/article/S1525-5050(14)00413-2/fulltext.

Porter, B.E., and Jacobson, C. (2013, December). Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy. Epilepsy & Behavior, 29(3), 574-7. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157067/.

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